An unusual type of colitis struck me in 2006. It mysteriously disappeared in 2014, the year I was diagnosed with Parkinson’s disease.
What was the connection between my Lymphocytic Colitis and PD? My physicians were mystified.
Recent research is identifying the gastrointestinal tract, as a probable starting place for PD. It’s quite an unfolding story.
Players include benign bacteria, inflammatory reaction, misfolded protein, and travel of a prion-like element from the gut to the brain along the vagus nerve.
This quite readable Scientific American article tells it well:
https://www.scientificamerican.com/article/does-parkinsons-begin-in-the-gut/